Takrolimusun sıçanlarda miyokardiyal iskemi / reperfüzyon hasarı üzerindeki koruyucu etkisi

Aim: Acute myocardial infarction is a major cause of morbidity and mortality worldwide. Although thrombolytic therapy primary percutaneous coronary intervention are the therapeutic approaches to reduce ischemic injury limit infarct size by providing reperfusion, process can itself induce cardiomyocyte death known as reperfusion injury. In addition effects on immunsuppression for organ transplantation, tacrolimus has diverse actions that result in amelioration ischemia/reperfusion (I/R) this study, we aimed evaluate I/R rats.
 Material Methods: Adult male Wistar albino rats (n=18; mean weight, 252±20 g; age, 46-54 days) were included study. Rats randomly assigned into three groups: Group 1 (sham, n=4), 2 (I/R+saline, control, n=7), 3 (tacrolimus+I/R, n=7). Tacrolimus (0.1 mg/kg) was administered an intravenous infusion first 15 min after 45 ischemia period. 
 Results: there no change area at risk, markedly reduced group when compared control (p